home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 424.1 KB |
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MacOS 8.1
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Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 36 38 30 30 7d |que_ID{Y|RB06800}|
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|000005d0| 6e 65 74 69 75 6d 2d 39 | 39 6d 20 43 50 49 20 61 |netium-9|9m CPI a|
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|00000600| 20 41 67 65 6e 74 20 69 | 6e 20 45 78 65 72 63 69 | Agent i|n Exerci|
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|00000620| 74 68 6f 72 7b 53 69 61 | 2c 20 53 54 42 0d 0a 48 |thor{Sia|, STB..H|
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|00000670| 4a 46 0d 0a 44 61 76 69 | 73 6f 6e 2c 20 41 0d 0a |JF..Davi|son, A..|
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|00000690| 69 6c 69 61 74 69 6f 6e | 7b 48 61 72 76 61 72 64 |iliation|{Harvard|
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|000007b0| 0a 24 50 61 67 65 7b 36 | 38 31 2d 36 38 37 7d 0d |.$Page{6|81-687}.|
|000007c0| 0a 24 44 61 74 65 7b 53 | 65 70 74 65 6d 62 65 72 |.$Date{S|eptember|
|000007d0| 20 31 39 38 37 7d 0d 0a | 24 59 42 56 6f 6c 7b 31 | 1987}..|$YBVol{1|
|000007e0| 39 38 39 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |989 Year| Book of|
|000007f0| 20 4d 65 64 69 63 69 6e | 65 2c 20 50 61 72 74 20 | Medicin|e, Part |
|00000800| 46 6f 75 72 7d 0d 0a 24 | 43 68 61 70 74 65 72 7b |Four}..$|Chapter{|
|00000810| 33 31 2d 32 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |31-2}..$|YBEditor|
|00000820| 7b 44 72 73 2e 20 52 6f | 67 65 72 73 2c 20 44 65 |{Drs. Ro|gers, De|
|00000830| 73 20 50 72 65 7a 2c 20 | 43 6c 69 6e 65 2c 20 42 |s Prez, |Cline, B|
|00000840| 72 61 75 6e 77 61 6c 64 | 2c 20 47 72 65 65 6e 62 |raunwald|, Greenb|
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|00000860| 70 73 74 65 69 6e 2c 20 | 61 6e 64 20 4d 61 6c 61 |pstein, |and Mala|
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|00000890| 2e 20 42 72 61 75 6e 77 | 61 6c 64 2c 20 4d 2e 44 |. Braunw|ald, M.D|
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|00000b60| 62 73 74 72 61 63 74 0d | 0a 0d 0a 20 20 20 20 20 |bstract.|... |
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|00001960| 65 72 79 20 44 69 73 65 | 61 73 65 0d 0a 0d 0a 2d |ery Dise|ase....-|
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|00001ab0| 28 4f 73 61 6b 61 20 55 | 6e 69 76 3b 20 53 61 6b |(Osaka U|niv; Sak|
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|000028d0| 65 6e 2d 72 65 6c 61 74 | 65 64 2c 20 69 6e 20 63 |en-relat|ed, in c|
|000028e0| 6f 72 6f 6e 61 72 79 20 | 61 72 74 65 72 79 0d 0a |oronary |artery..|
|000028f0| 64 69 73 65 61 73 65 3b | 20 41 6e 74 69 67 65 6e |disease;| Antigen|
|00002900| 2c 20 41 6e 74 69 67 65 | 6e 73 20 66 69 62 72 69 |, Antige|ns fibri|
|00002910| 6e 2d 72 65 6c 61 74 65 | 64 2c 20 69 6e 20 63 6f |n-relate|d, in co|
|00002920| 72 6f 6e 61 72 79 20 61 | 72 74 65 72 79 20 64 69 |ronary a|rtery di|
|00002930| 73 65 61 73 65 7d 0d 0a | 24 4a 6f 75 72 6e 61 6c |sease}..|$Journal|
|00002940| 7b 4e 20 45 6e 67 6c 20 | 4a 20 4d 65 64 7d 0d 0a |{N Engl |J Med}..|
|00002950| 24 56 6f 6c 75 6d 65 7b | 33 31 37 7d 0d 0a 24 50 |$Volume{|317}..$P|
|00002960| 61 67 65 7b 31 33 36 31 | 2d 31 33 36 35 7d 0d 0a |age{1361|-1365}..|
|00002970| 24 44 61 74 65 7b 4e 6f | 76 20 32 36 2c 20 31 39 |$Date{No|v 26, 19|
|00002980| 38 37 7d 0d 0a 24 59 42 | 56 6f 6c 7b 31 39 38 39 |87}..$YB|Vol{1989|
|00002990| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 4d 65 | Year Bo|ok of Me|
|000029a0| 64 69 63 69 6e 65 2c 20 | 50 61 72 74 20 46 6f 75 |dicine, |Part Fou|
|000029b0| 72 7d 0d 0a 24 43 68 61 | 70 74 65 72 7b 33 31 2d |r}..$Cha|pter{31-|
|000029c0| 34 7d 0d 0a 24 59 42 45 | 64 69 74 6f 72 7b 44 72 |4}..$YBE|ditor{Dr|
|000029d0| 73 2e 20 52 6f 67 65 72 | 73 2c 20 44 65 73 20 50 |s. Roger|s, Des P|
|000029e0| 72 65 7a 2c 20 43 6c 69 | 6e 65 2c 20 42 72 61 75 |rez, Cli|ne, Brau|
|000029f0| 6e 77 61 6c 64 2c 20 47 | 72 65 65 6e 62 65 72 67 |nwald, G|reenberg|
|00002a00| 65 72 2c 20 57 69 6c 73 | 6f 6e 2c 20 45 70 73 74 |er, Wils|on, Epst|
|00002a10| 65 69 6e 2c 20 61 6e 64 | 20 4d 61 6c 61 77 69 73 |ein, and| Malawis|
|00002a20| 74 61 7d 0d 0a 24 54 61 | 62 6c 65 7b 7d 0d 0a 24 |ta}..$Ta|ble{}..$|
|00002a30| 43 6f 6d 6d 65 6e 74 61 | 74 6f 72 7b 45 2e 20 42 |Commenta|tor{E. B|
|00002a40| 72 61 75 6e 77 61 6c 64 | 2c 20 4d 2e 44 2e 7d 0d |raunwald|, M.D.}.|
|00002a50| 0a 0d 0a 43 6f 70 79 72 | 69 67 68 74 20 28 63 29 |...Copyr|ight (c)|
|00002a60| 20 59 65 61 72 20 42 6f | 6f 6b 20 4d 65 64 69 63 | Year Bo|ok Medic|
|00002a70| 61 6c 20 50 75 62 6c 69 | 73 68 65 72 73 2c 20 49 |al Publi|shers, I|
|00002a80| 6e 63 2e 2c 20 31 39 38 | 39 0d 0a 0d 0a 31 39 38 |nc., 198|9....198|
|00002a90| 39 20 59 65 61 72 20 42 | 6f 6f 6b 20 6f 66 20 4d |9 Year B|ook of M|
|00002aa0| 65 64 69 63 69 6e 65 20 | 28 52 29 0d 0a 0d 0a 50 |edicine |(R)....P|
|00002ab0| 61 72 74 20 46 6f 75 72 | 3a 20 20 54 68 65 20 48 |art Four|: The H|
|00002ac0| 65 61 72 74 20 61 6e 64 | 20 43 61 72 64 69 6f 76 |eart and| Cardiov|
|00002ad0| 61 73 63 75 6c 61 72 20 | 44 69 73 65 61 73 65 0d |ascular |Disease.|
|00002ae0| 0a 0d 0a 43 68 61 70 74 | 65 72 20 33 31 2d 2d 43 |...Chapt|er 31--C|
|00002af0| 68 72 6f 6e 69 63 20 43 | 6f 72 6f 6e 61 72 79 20 |hronic C|oronary |
|00002b00| 41 72 74 65 72 79 20 44 | 69 73 65 61 73 65 0d 0a |Artery D|isease..|
|00002b10| 0d 0a 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |..------|--------|
|00002b20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b60| 2d 2d 0d 0a 46 69 62 72 | 69 6e 20 61 6e 64 20 46 |--..Fibr|in and F|
|00002b70| 69 62 72 69 6e 6f 67 65 | 6e 2d 52 65 6c 61 74 65 |ibrinoge|n-Relate|
|00002b80| 64 20 41 6e 74 69 67 65 | 6e 73 20 69 6e 20 50 61 |d Antige|ns in Pa|
|00002b90| 74 69 65 6e 74 73 20 57 | 69 74 68 20 53 74 61 62 |tients W|ith Stab|
|00002ba0| 6c 65 20 61 6e 64 20 55 | 6e 73 74 61 62 6c 65 0d |le and U|nstable.|
|00002bb0| 0a 43 6f 72 6f 6e 61 72 | 79 20 41 72 74 65 72 79 |.Coronar|y Artery|
|00002bc0| 20 44 69 73 65 61 73 65 | 0d 0a 0d 0a 4b 72 75 73 | Disease|....Krus|
|00002bd0| 6b 61 6c 20 4a 42 2c 20 | 43 6f 6d 6d 65 72 66 6f |kal JB, |Commerfo|
|00002be0| 72 64 20 50 4a 2c 20 46 | 72 61 6e 6b 73 20 4a 4a |rd PJ, F|ranks JJ|
|00002bf0| 2c 20 4b 69 72 73 63 68 | 20 52 45 0d 0a 28 55 6e |, Kirsch| RE..(Un|
|00002c00| 69 76 20 6f 66 20 43 61 | 70 65 20 54 6f 77 6e 3b |iv of Ca|pe Town;|
|00002c10| 20 47 72 6f 6f 74 65 20 | 53 63 68 75 75 72 20 48 | Groote |Schuur H|
|00002c20| 6f 73 70 2c 20 43 61 70 | 65 20 54 6f 77 6e 3b 20 |osp, Cap|e Town; |
|00002c30| 56 61 6e 64 65 72 62 69 | 6c 74 20 55 6e 69 76 29 |Vanderbi|lt Univ)|
|00002c40| 0d 0a 4e 20 45 6e 67 6c | 20 4a 20 4d 65 64 20 33 |..N Engl| J Med 3|
|00002c50| 31 37 3a 31 33 36 31 2d | 31 33 36 35 2c 20 4e 6f |17:1361-|1365, No|
|00002c60| 76 20 32 36 2c 20 31 39 | 38 37 0d 0a 2d 2d 2d 2d |v 26, 19|87..----|
|00002c70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002c80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002c90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ca0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002cb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00002cc0| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|00002cd0| 20 43 6f 72 6f 6e 61 72 | 79 20 61 72 74 65 72 79 | Coronar|y artery|
|00002ce0| 20 74 68 72 6f 6d 62 6f | 73 69 73 20 6d 61 79 20 | thrombo|sis may |
|00002cf0| 70 6c 61 79 20 61 20 72 | 6f 6c 65 20 69 6e 20 74 |play a r|ole in t|
|00002d00| 68 65 20 70 61 74 68 6f | 67 65 6e 65 73 69 73 20 |he patho|genesis |
|00002d10| 6f 66 20 75 6e 73 74 61 | 62 6c 65 0d 0a 61 6e 67 |of unsta|ble..ang|
|00002d20| 69 6e 61 20 61 74 20 72 | 65 73 74 2e 20 20 54 65 |ina at r|est. Te|
|00002d30| 72 6d 69 6e 61 6c 20 62 | 72 65 61 6b 64 6f 77 6e |rminal b|reakdown|
|00002d40| 20 66 72 61 67 6d 65 6e | 74 73 20 73 70 65 63 69 | fragmen|ts speci|
|00002d50| 66 69 63 20 66 6f 72 20 | 66 69 62 72 69 6e 20 61 |fic for |fibrin a|
|00002d60| 6e 64 20 66 69 62 72 69 | 6e 6f 67 65 6e 0d 0a 61 |nd fibri|nogen..a|
|00002d70| 6e 64 20 69 6e 74 65 72 | 6d 65 64 69 61 74 65 20 |nd inter|mediate |
|00002d80| 66 72 61 67 6d 65 6e 74 | 73 20 70 72 6f 64 75 63 |fragment|s produc|
|00002d90| 65 64 20 64 75 72 69 6e | 67 20 66 6f 72 6d 61 74 |ed durin|g format|
|00002da0| 69 6f 6e 20 6f 66 20 66 | 69 62 72 69 6e 20 77 65 |ion of f|ibrin we|
|00002db0| 72 65 20 6d 65 61 73 75 | 72 65 64 20 69 6e 0d 0a |re measu|red in..|
|00002dc0| 70 61 74 69 65 6e 74 73 | 20 77 69 74 68 20 73 74 |patients| with st|
|00002dd0| 61 62 6c 65 20 61 6e 64 | 20 75 6e 73 74 61 62 6c |able and| unstabl|
|00002de0| 65 20 61 6e 67 69 6e 61 | 20 61 6e 64 20 69 6e 20 |e angina| and in |
|00002df0| 70 61 74 69 65 6e 74 73 | 20 77 69 74 68 20 61 63 |patients| with ac|
|00002e00| 75 74 65 20 6d 79 6f 63 | 61 72 64 69 61 6c 0d 0a |ute myoc|ardial..|
|00002e10| 69 6e 66 61 72 63 74 69 | 6f 6e 20 28 4d 49 29 2e |infarcti|on (MI).|
|00002e20| 0d 0a 20 20 20 20 20 50 | 61 74 69 65 6e 74 73 20 |.. P|atients |
|00002e30| 77 69 74 68 20 63 61 72 | 64 69 61 63 20 63 68 65 |with car|diac che|
|00002e40| 73 74 20 70 61 69 6e 20 | 77 65 72 65 20 6d 61 74 |st pain |were mat|
|00002e50| 63 68 65 64 20 77 69 74 | 68 20 62 6f 74 68 20 68 |ched wit|h both h|
|00002e60| 65 61 6c 74 68 79 20 61 | 6e 64 20 69 6c 6c 0d 0a |ealthy a|nd ill..|
|00002e70| 63 6f 6e 74 72 6f 6c 73 | 20 77 68 6f 20 68 61 64 |controls| who had|
|00002e80| 20 70 61 69 6e 20 6f 66 | 20 6e 6f 6e 63 61 72 64 | pain of| noncard|
|00002e90| 69 61 63 20 6f 72 69 67 | 69 6e 2e 20 20 50 61 74 |iac orig|in. Pat|
|00002ea0| 69 65 6e 74 73 20 77 69 | 74 68 20 63 68 65 73 74 |ients wi|th chest|
|00002eb0| 20 70 61 69 6e 20 77 65 | 72 65 0d 0a 73 75 62 64 | pain we|re..subd|
|00002ec0| 69 76 69 64 65 64 20 69 | 6e 74 6f 20 67 72 6f 75 |ivided i|nto grou|
|00002ed0| 70 73 20 61 63 63 6f 72 | 64 69 6e 67 20 74 6f 20 |ps accor|ding to |
|00002ee0| 77 68 65 74 68 65 72 20 | 74 68 65 79 20 68 61 64 |whether |they had|
|00002ef0| 20 70 61 69 6e 20 61 74 | 20 72 65 73 74 20 6f 72 | pain at| rest or|
|00002f00| 20 6f 6e 0d 0a 65 78 65 | 72 63 69 73 65 2e 20 20 | on..exe|rcise. |
|00002f10| 41 20 66 69 66 74 68 20 | 67 72 6f 75 70 20 77 61 |A fifth |group wa|
|00002f20| 73 20 63 6f 6d 70 6f 73 | 65 64 20 6f 66 20 70 61 |s compos|ed of pa|
|00002f30| 74 69 65 6e 74 73 20 77 | 69 74 68 20 61 63 75 74 |tients w|ith acut|
|00002f40| 65 20 4d 49 2e 20 20 53 | 65 72 75 6d 0d 0a 63 6f |e MI. S|erum..co|
|00002f50| 6e 63 65 6e 74 72 61 74 | 69 6f 6e 73 20 6f 66 20 |ncentrat|ions of |
|00002f60| 66 69 62 72 69 6e 2d 72 | 65 6c 61 74 65 64 20 61 |fibrin-r|elated a|
|00002f70| 6e 74 69 67 65 6e 2c 20 | 44 20 64 69 6d 65 72 2c |ntigen, |D dimer,|
|00002f80| 20 61 6e 64 20 66 69 62 | 72 69 6e 20 6d 6f 6e 6f | and fib|rin mono|
|00002f90| 6d 65 72 20 77 65 72 65 | 0d 0a 6d 65 61 73 75 72 |mer were|..measur|
|00002fa0| 65 64 20 69 6e 20 61 6c | 6c 20 67 72 6f 75 70 73 |ed in al|l groups|
|00002fb0| 2e 0d 0a 20 20 20 20 20 | 54 68 65 20 63 6f 6e 63 |... |The conc|
|00002fc0| 65 6e 74 72 61 74 69 6f | 6e 20 6f 66 20 66 69 62 |entratio|n of fib|
|00002fd0| 72 69 6e 2d 72 65 6c 61 | 74 65 64 20 61 6e 74 69 |rin-rela|ted anti|
|00002fe0| 67 65 6e 20 77 61 73 20 | 6e 6f 72 6d 61 6c 20 69 |gen was |normal i|
|00002ff0| 6e 20 63 6f 6e 74 72 6f | 6c 73 20 77 69 74 68 0d |n contro|ls with.|
|00003000| 0a 6e 6f 6e 63 61 72 64 | 69 61 63 20 70 61 69 6e |.noncard|iac pain|
|00003010| 20 61 6e 64 20 69 6e 20 | 70 61 74 69 65 6e 74 73 | and in |patients|
|00003020| 20 77 69 74 68 20 63 68 | 72 6f 6e 69 63 20 73 74 | with ch|ronic st|
|00003030| 61 62 6c 65 20 61 6e 67 | 69 6e 61 3b 20 69 74 20 |able ang|ina; it |
|00003040| 77 61 73 20 69 6e 63 72 | 65 61 73 65 64 20 69 6e |was incr|eased in|
|00003050| 0d 0a 70 61 74 69 65 6e | 74 73 20 77 69 74 68 20 |..patien|ts with |
|00003060| 61 63 75 74 65 20 4d 49 | 20 6f 72 20 75 6e 73 74 |acute MI| or unst|
|00003070| 61 62 6c 65 20 61 6e 67 | 69 6e 61 2e 20 20 43 6f |able ang|ina. Co|
|00003080| 6e 63 65 6e 74 72 61 74 | 69 6f 6e 73 20 6f 66 20 |ncentrat|ions of |
|00003090| 44 20 64 69 6d 65 72 20 | 77 65 72 65 20 6c 6f 77 |D dimer |were low|
|000030a0| 65 72 0d 0a 69 6e 20 62 | 6f 74 68 20 63 6f 6e 74 |er..in b|oth cont|
|000030b0| 72 6f 6c 20 67 72 6f 75 | 70 73 20 61 6e 64 20 69 |rol grou|ps and i|
|000030c0| 6e 20 70 61 74 69 65 6e | 74 73 20 77 69 74 68 20 |n patien|ts with |
|000030d0| 73 74 61 62 6c 65 20 61 | 6e 67 69 6e 61 20 74 68 |stable a|ngina th|
|000030e0| 61 6e 20 69 6e 20 70 61 | 74 69 65 6e 74 73 20 77 |an in pa|tients w|
|000030f0| 69 74 68 0d 0a 75 6e 73 | 74 61 62 6c 65 20 61 6e |ith..uns|table an|
|00003100| 67 69 6e 61 20 6f 72 20 | 61 63 75 74 65 20 4d 49 |gina or |acute MI|
|00003110| 2e 20 20 54 68 65 20 68 | 69 67 68 65 73 74 20 63 |. The h|ighest c|
|00003120| 6f 6e 63 65 6e 74 72 61 | 74 69 6f 6e 73 20 6f 66 |oncentra|tions of|
|00003130| 20 66 69 62 72 69 6e 20 | 6d 6f 6e 6f 6d 65 72 20 | fibrin |monomer |
|00003140| 77 65 72 65 0d 0a 66 6f | 75 6e 64 20 69 6e 20 70 |were..fo|und in p|
|00003150| 61 74 69 65 6e 74 73 20 | 77 69 74 68 20 61 63 75 |atients |with acu|
|00003160| 74 65 20 4d 49 2e 20 20 | 50 61 74 69 65 6e 74 73 |te MI. |Patients|
|00003170| 20 77 69 74 68 20 75 6e | 73 74 61 62 6c 65 20 61 | with un|stable a|
|00003180| 6e 67 69 6e 61 20 68 61 | 64 20 6d 6f 64 65 72 61 |ngina ha|d modera|
|00003190| 74 65 0d 0a 63 6f 6e 63 | 65 6e 74 72 61 74 69 6f |te..conc|entratio|
|000031a0| 6e 73 2c 20 77 68 65 72 | 65 61 73 20 69 6c 6c 20 |ns, wher|eas ill |
|000031b0| 63 6f 6e 74 72 6f 6c 73 | 20 61 6e 64 20 70 61 74 |controls| and pat|
|000031c0| 69 65 6e 74 73 20 77 69 | 74 68 20 73 74 61 62 6c |ients wi|th stabl|
|000031d0| 65 20 61 6e 67 69 6e 61 | 20 68 61 64 20 6e 6f 72 |e angina| had nor|
|000031e0| 6d 61 6c 0d 0a 63 6f 6e | 63 65 6e 74 72 61 74 69 |mal..con|centrati|
|000031f0| 6f 6e 73 2e 0d 0a 20 20 | 20 20 20 49 74 20 61 70 |ons... | It ap|
|00003200| 70 65 61 72 73 20 74 68 | 61 74 20 74 68 65 72 65 |pears th|at there|
|00003210| 20 69 73 20 61 6e 20 61 | 63 74 69 76 65 20 74 68 | is an a|ctive th|
|00003220| 72 6f 6d 62 6f 74 69 63 | 20 70 72 6f 63 65 73 73 |rombotic| process|
|00003230| 20 69 6e 20 70 61 74 69 | 65 6e 74 73 20 77 69 74 | in pati|ents wit|
|00003240| 68 0d 0a 61 63 75 74 65 | 20 4d 49 20 6f 72 20 75 |h..acute| MI or u|
|00003250| 6e 73 74 61 62 6c 65 20 | 61 6e 67 69 6e 61 20 61 |nstable |angina a|
|00003260| 74 20 72 65 73 74 2e 20 | 20 49 66 20 75 6e 73 74 |t rest. | If unst|
|00003270| 61 62 6c 65 20 61 6e 67 | 69 6e 61 20 61 74 20 72 |able ang|ina at r|
|00003280| 65 73 74 20 69 73 20 69 | 6e 64 65 65 64 0d 0a 61 |est is i|ndeed..a|
|00003290| 73 73 6f 63 69 61 74 65 | 64 20 77 69 74 68 20 74 |ssociate|d with t|
|000032a0| 68 72 6f 6d 62 6f 73 69 | 73 20 61 6e 64 20 73 70 |hrombosi|s and sp|
|000032b0| 6f 6e 74 61 6e 65 6f 75 | 73 20 6c 79 73 69 73 2c |ontaneou|s lysis,|
|000032c0| 20 70 72 6f 67 72 65 73 | 73 69 6f 6e 20 74 6f 20 | progres|sion to |
|000032d0| 4d 49 20 6d 61 79 20 62 | 65 0d 0a 70 72 65 76 65 |MI may b|e..preve|
|000032e0| 6e 74 65 64 20 62 79 20 | 74 68 72 6f 6d 62 6f 6c |nted by |thrombol|
|000032f0| 79 74 69 63 2c 20 61 6e | 74 69 70 6c 61 74 65 6c |ytic, an|tiplatel|
|00003300| 65 74 2c 20 6f 72 20 61 | 6e 74 69 63 6f 61 67 75 |et, or a|nticoagu|
|00003310| 6c 61 6e 74 20 74 68 65 | 72 61 70 79 2e 0d 0a 0d |lant the|rapy....|
|00003320| 0a 50 6f 73 74 2d 43 6f | 6d 6d 65 6e 74 0d 0a 0d |.Post-Co|mment...|
|00003330| 0a 20 20 20 20 20 54 68 | 65 20 6e 6f 74 69 6f 6e |. Th|e notion|
|00003340| 20 74 68 61 74 20 61 20 | 70 61 72 74 69 61 6c 6c | that a |partiall|
|00003350| 79 20 6f 63 63 6c 75 73 | 69 76 65 20 74 68 72 6f |y occlus|ive thro|
|00003360| 6d 62 75 73 20 69 73 20 | 65 74 69 6f 6c 6f 67 69 |mbus is |etiologi|
|00003370| 63 61 6c 6c 79 20 69 6d | 70 6f 72 74 61 6e 74 0d |cally im|portant.|
|00003380| 0a 69 6e 20 75 6e 73 74 | 61 62 6c 65 20 61 6e 67 |.in unst|able ang|
|00003390| 69 6e 61 20 69 73 20 73 | 75 70 70 6f 72 74 65 64 |ina is s|upported|
|000033a0| 20 6e 6f 74 20 6f 6e 6c | 79 20 62 79 20 61 6e 67 | not onl|y by ang|
|000033b0| 69 6f 67 72 61 70 68 69 | 63 20 61 6e 64 20 61 6e |iographi|c and an|
|000033c0| 67 69 6f 73 63 6f 70 69 | 63 20 73 74 75 64 69 65 |gioscopi|c studie|
|000033d0| 73 0d 0a 28 73 65 65 20 | 41 62 73 74 72 61 63 74 |s..(see |Abstract|
|000033e0| 20 33 31 2d 33 29 2c 20 | 62 75 74 20 61 6c 73 6f | 31-3), |but also|
|000033f0| 20 62 79 20 74 68 65 20 | 6f 62 73 65 72 76 61 74 | by the |observat|
|00003400| 69 6f 6e 20 74 68 61 74 | 20 70 6c 61 74 65 6c 65 |ion that| platele|
|00003410| 74 20 61 63 74 69 76 61 | 74 69 6f 6e 20 61 6e 64 |t activa|tion and|
|00003420| 0d 0a 74 68 72 6f 6d 62 | 69 6e 20 67 65 6e 65 72 |..thromb|in gener|
|00003430| 61 74 69 6f 6e 20 6f 63 | 63 75 72 20 69 6e 20 74 |ation oc|cur in t|
|00003440| 68 65 73 65 20 70 61 74 | 69 65 6e 74 73 2e 20 20 |hese pat|ients. |
|00003450| 49 6e 20 74 68 65 20 31 | 39 38 38 20 59 45 41 52 |In the 1|988 YEAR|
|00003460| 20 42 4f 4f 4b 20 4f 46 | 20 4d 45 44 49 43 49 4e | BOOK OF| MEDICIN|
|00003470| 45 0d 0a 28 70 70 20 33 | 34 37 2d 33 34 38 29 20 |E..(pp 3|47-348) |
|00003480| 69 74 20 77 61 73 20 70 | 6f 69 6e 74 65 64 20 6f |it was p|ointed o|
|00003490| 75 74 20 74 68 61 74 20 | 66 69 62 72 69 6e 6f 70 |ut that |fibrinop|
|000034a0| 65 70 74 69 64 65 20 41 | 2c 20 61 20 70 65 70 74 |eptide A|, a pept|
|000034b0| 69 64 65 20 72 65 6c 65 | 61 73 65 64 20 66 72 6f |ide rele|ased fro|
|000034c0| 6d 0d 0a 74 68 65 20 61 | 6c 70 68 61 20 63 68 61 |m..the a|lpha cha|
|000034d0| 69 6e 20 6f 66 20 66 69 | 62 72 69 6e 6f 67 65 6e |in of fi|brinogen|
|000034e0| 20 6f 6e 20 74 68 65 20 | 73 70 65 63 69 66 69 63 | on the |specific|
|000034f0| 20 61 63 74 69 6f 6e 20 | 6f 66 20 74 68 72 6f 6d | action |of throm|
|00003500| 62 69 6e 2c 20 69 73 20 | 61 20 73 65 6e 73 69 74 |bin, is |a sensit|
|00003510| 69 76 65 0d 0a 6d 61 72 | 6b 65 72 20 6f 66 20 66 |ive..mar|ker of f|
|00003520| 69 62 72 69 6e 20 66 6f | 72 6d 61 74 69 6f 6e 20 |ibrin fo|rmation |
|00003530| 61 6e 64 20 74 68 65 20 | 72 65 63 65 6e 74 20 6f |and the |recent o|
|00003540| 63 63 75 72 72 65 6e 63 | 65 20 6f 66 20 74 68 72 |ccurrenc|e of thr|
|00003550| 6f 6d 62 6f 73 69 73 2e | 20 20 54 68 65 20 66 69 |ombosis.| The fi|
|00003560| 6e 64 69 6e 67 0d 0a 69 | 6e 20 74 68 65 20 73 74 |nding..i|n the st|
|00003570| 75 64 79 20 61 62 73 74 | 72 61 63 74 65 64 20 61 |udy abst|racted a|
|00003580| 62 6f 76 65 20 6f 66 20 | 65 6c 65 76 61 74 69 6f |bove of |elevatio|
|00003590| 6e 73 20 6f 66 20 66 69 | 62 72 69 6e 2d 72 65 6c |ns of fi|brin-rel|
|000035a0| 61 74 65 64 20 61 6e 74 | 69 67 65 6e 2c 20 44 20 |ated ant|igen, D |
|000035b0| 64 69 6d 65 72 2c 0d 0a | 61 6e 64 20 66 69 62 72 |dimer,..|and fibr|
|000035c0| 69 6e 20 6d 6f 6e 6f 6d | 65 72 2c 20 61 6c 6c 20 |in monom|er, all |
|000035d0| 70 72 6f 64 75 63 74 73 | 20 6f 66 20 74 68 72 6f |products| of thro|
|000035e0| 6d 62 6f 73 69 73 20 6f | 72 20 74 68 72 6f 6d 62 |mbosis o|r thromb|
|000035f0| 6f 6c 79 73 69 73 2c 20 | 73 74 72 6f 6e 67 6c 79 |olysis, |strongly|
|00003600| 20 73 75 70 70 6f 72 74 | 0d 0a 74 68 65 20 6e 6f | support|..the no|
|00003610| 74 69 6f 6e 20 74 68 61 | 74 20 75 6e 73 74 61 62 |tion tha|t unstab|
|00003620| 6c 65 20 61 6e 67 69 6e | 61 2c 20 6c 69 6b 65 20 |le angin|a, like |
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|00003ae0| 43 68 61 70 74 65 72 20 | 33 31 2d 2d 43 68 72 6f |Chapter |31--Chro|
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|00003c60| 20 41 6e 67 65 6c 65 73 | 3b 20 55 6e 69 76 20 6f | Angeles|; Univ o|
|00003c70| 66 20 43 61 6c 69 66 6f | 72 6e 69 61 2c 20 4c 6f |f Califo|rnia, Lo|
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|00003d40| 2d 0d 0a 0d 0a 41 62 73 | 74 72 61 63 74 0d 0a 0d |-....Abs|tract...|
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|00005e60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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+--------+-------------------------+-------------------------+--------+--------+
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